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Part II—Further Medical Testing No lymph nodes could be palpated in Joe’s neck o
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Part II—Further Medical Testing
No lymph nodes could be palpated in Joe’s neck or armpits. His heart, lungs, liver, and spleen were of normal size. Suspecting a problem with Joe’s immune system, his physicians took a blood sample for a complete blood count (CBC). The CBC revealed the following results:
Table 1. Complete Blood Count (CBC)
Cell Type Joe’s Blood Count Normal Range
Red blood cells 3.1X106/microliter 2.7X106 – 4.9X106/microliter
Platelets 180,000/microliter 150,000-440,000/microliter
Total white blood cells 3500/microliter 6000-17500/microliter
Neutrophils 2600/microliter 2000-7500/microliter
Eosinophils 170/microliter 0-400/microliter
Monocytes 300/microliter 200-800/microliter
Basophils 10/microliter 0-100/microliter
Lymphocytes 350/microliter 1000-4000/microliter
T cells 2% of total lymphocytes 60 to 80% of total lymphocytes
B cells <1% of total lymphocytes 15-25% of total lymphocytes NK cells 90% of total lymphocytes 10-20% of total lymphocytes Questions 1. Which types of cells are the most affected? Provide evidence to support your answer. 2. Based on this information, identify the stage in immune cell development (also called hematopoiesis) that appears to be defective in Baby Joe’s immune system. 3. Do you think that Joe will have normal levels of antibodies present in his blood? Why or why not? 4. How do these data help explain Baby Joe’s symptoms? 5. List molecular defects that could result in the immune system phenotype observed in Baby Joe. Be ready to explain your answers.